INCI Name: Biotinoyl Tripeptide-1

CAS No.: 299157-54-3

Appearance: White to off-white powder

Assay (HPLC): ≥98.0%

Molecular Weight: ~632.8 g/mol

Solubility: Soluble in water and glycols

Overview

Biotin Tripeptide-1 is a synthetic biomimetic peptide composed of biotin (vitamin B7) conjugated with a tripeptide sequence (GHK). It functions as a cell-signaling agent that activates extracellular matrix (ECM) regeneration, making it a versatile active ingredient for high-performance hair and skin care formulations.

Key Technical Benefits

Hair Follicle Stimulation – Promotes keratinocyte proliferation; clinical studies show increased hair growth by 58% at 2 ppm and 121% at 5 ppm versus controls.

ECM Reinforcement – Upregulates collagen IV and laminin-5 synthesis, strengthening the dermal-epidermal junction and anchoring hair bulbs.

Anti-Aging & Repair – Accelerates damaged skin barrier recovery and improves firmness by boosting fibroblast activity.

Antioxidant Protection – Reduces reactive oxygen species (ROS) production, mitigating oxidative stress in scalp and skin tissues.

Recommended Use Levels

Application Dosage (active)

Hair serums / tonics 0.5 – 5 ppm

Anti-aging creams / lotions 1 – 10 ppm

Shampoos & conditioners 2 – 5 ppm

Eyelash / eyebrow enhancers 1 – 3 ppm

Formulation Guidelines

Stable at pH 4.0–8.0 and temperatures up to 60°C.

Compatible with most preservatives, humectants, and surfactants.

Add at the cooling phase (below 45°C) for optimal activity.

Safety & Regulatory

Non-irritant, non-sensitizing (validated by repeated patch tests).

Approved for use in cosmetic products under EU, US, and China regulations.

Dermatologically tested; suitable for sensitive skin and fragile hair.

Packaging & Storage

Available in 1g, 10g, 50g, and bulk custom packs.

Store in a cool, dry place, protected from light; shelf life 24 months (unopened).

For bulk inquiries, technical datasheets, or sample requests, please contact our sales team.