CAS number：103-16-2
molecular formula：C13H12O2
molecular weight：200.23
EINECS number：203-083-3

English synonyms

HYDROQUINONE MONOBENZYL ETHER;Benzyl hydroquinone;BENZYL P-HYDROXYPHENYL ETHER;MONOBENZONE;PBP;P-BENZYLOXYPHENOL;P-HYDROXYPHENYL BENZYL ETHER;4-BENZYLOXYPHENOL

Related categories

APIs; pharmaceutical intermediates; organic building blocks; general reagents; phenol; standard products; aromatic hydrocarbons; 4-benzyloxyphenol; phenols; plant extracts; raw materials; small molecule inhibitors; organic chemicals; fluorine chemistry, halogenated Hydrocarbon Halogenated Hydrocarbons; Pharmaceutical Raw Materials; Functional Raw Materials; Fine Chemicals; Intermediates; Whitening and Sunscreen; Organic Chemical Raw Materials; Building Blocks for Liquid Crystals);Building Blocks for Liquid Crystals;Functional Materials;treat Vitiligo;whiten agent;cosmetics;B;Bioactive Small Molecules;Building Blocks;C9 to C20+;Cell Biology;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds; Phenols;API;SANODIN;chemical raw materials;cosmetic raw materials;chemical intermediates;standards-standard products of traditional Chinese medicine;drug impurities and intermediates;additives;organic chemical raw materials;daily chemical raw materials;103-16-2

Introduction

Monobenzone is a topical depigmenting agent used to treat hyperpigmentation, such as various pigmentation spots, age spots, melanoma, etc., with obvious results. It can decompose melanin in the skin, prevent the formation of melanin in the skin, and restore the skin to a healthy color without destroying melanocytes. The toxicity is very light. It is usually made into ointment or liniment. . At present, there are no drugs for the treatment of pigmentation in my country, and the cosmetics used for the treatment of pigmentation have little effect, and some cosmetics add a large amount of harmful substances such as hydroquinone and metallic mercury to achieve the effect of freckle and whitening. Monobenzone is developed into anti-freckle drugs or cosmetics, with good effect and low toxicity, which can meet the urgent needs of a large number of yellow people suffering from pigmentation, and will be welcomed by domestic and foreign markets.

●  Monobenzone is a topical depigmenting agent used to treat hyperpigmentation, such as various pigmentation spots, age spots, melanoma, etc., with obvious effects. It can decompose melanin in the skin, prevent the production of melanin in the skin, and restore the skin to a healthy color without destroying melanin cells.

●  Used as pharmaceutical intermediate

●  Monobenzone was synthesized by using hydroquinone, sodium hydroxide and benzyl chloride as raw materials and N,N-dimethylformamide (DMF) as solvent under microwave irradiation. The effects of molar ratio of reactants, microwave radiation power and radiation time on the yield of monobenzone were investigated by single factor experiment. The experimental results show that: when n (benzyl chloride): n (hydroquinone): n (sodium hydroxide) = 1: 1.4: 1.4, DMF15mL, microwave radiation power is 320W, radiation time is 60s, monobenzene The yield was 63.79%.

●  Add 2.63g (0.028mol) of hydroquinone to a 100mL conical flask, weigh 1.12g (0.028mol) of sodium hydroxide, add 8mL of water, and add dropwise to the solution containing hydroquinone after the sodium hydroxide is dissolved. In the conical flask, shake well, then add 15 mL of DMF and 2.52 g (0.02 mol) of benzyl chloride, and irradiate the reaction for 60 s under the condition of microwave radiation power of 320 W. After the reaction was completed, it was cooled to room temperature. First, adjust to alkaline with 10% sodium hydroxide, filter with suction, and wash the filter cake with 10% sodium hydroxide until the filtrate is colorless (the filter cake is hydroquinone dibenzyl ether, which can be recycled). The filtrate was acidified with hydrochloric acid to completely separate out monobenzone. After suction filtration and washing with ice water, the filtrate was recrystallized with alcohol and water, and decolorized with activated carbon to obtain 2.55 g of white solid with a yield of 63.79%.