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CAS number：67-20-9
molecular formula：C8H6N4O5
molecular weight：238.16
EINECS number：200-646-5
1-(((5-nitro-2-furanyl)methylene)amino)-2,4-imidazolidinedione;1-(5-NITRO-2-FURFURYLIDENEAMINO)HYDANTOIN;1-[(5-nitrofurfurylidene)amino]hydantoin;LABOTEST-BB LT00134625;FURADOXYL;N-(5-NITRO-2-FURFURYLIDENE)-1-AMINOHYDANTOIN;NITROFURANTOIN;NITROFURANTOINE
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Nitrofurantoin, also known as nitrofurantoin, nitrofuranidine, nitrofurantoin, nitronitrofurantoin, chemical name 1-[[(5-nitro-2-furanyl)methylene]amino]-24-imidazolidinedioe, is a synthetic antibacterial drug It has a broad antibacterial spectrum and has antibacterial effects on most Gram-positive and negative bacteria, such as Staphylococcus aureus, Escherichia coli, Staphylococcus albus and Streptococcus pyogenes. Clinically, it is commonly used for urinary tract infections caused by sensitive bacteria, such as pyelonephritis and urinary tract infections. cystitis and prostatitis.
| Melting point | 268°C |
| Boiling point | 380.75°C (rough estimate) |
| Density | 1.5824 (rough estimate) |
| Refractive index | 1.6700 (estimate) |
| Storage conditions | Keep in dark place,Inert atmosphere,Room temperature |
| Solubility | DMF: soluble50mg/mL |
| Shape | crystalline |
| Acidity coefficient(pKa) | 7.2(at 25℃) |
| Color | yellow |
| Water solubility | <0.01 g/100 mL at 19 ºC |
| Sensitive | Light Sensitive & Hygroscopic |
λmax | 358nm(MeOH)(lit.) |
Merck | 14,6599 |
BRN | 893207 |
| Stability | Stability Stable, but light-sensitive. Combustible. Incompatible with strong oxidizing agents, strong alkalies, strong acids. Decomposes upon contact with most metals other than stainless steel and aluminium. |
| CAS database | 67-20-9(CAS DataBase Reference) |
Orange-yellow needle crystals. Melting point 270-272 ° C (decomposition). The number of milligrams soluble in 100ml of the following solvents: water 19.0, 95% ethanol 51.0, acetone 510, DMF8000. Almost insoluble in chloroform. When exposed to light, the color becomes darker, odorless, and tastes bitter.
● This product is an excellent antibacterial drug. It absorbs rapidly and completely after oral administration, and excretes quickly. The excretion in urine can reach 40-50%. It is often used to treat urinary tract infections caused by various sensitive bacteria. Acute urinary tract infection caused by Bacillus has good curative effect.
● It is an excellent antibacterial drug with a wide antibacterial spectrum and is suitable for urinary tract infections such as pyelonephritis, pyelitis and cystitis.
● Semicarbazide is produced by condensation of hydrazine hydrate and urea, and then acetone semicarbazide is obtained by condensation with acetone. Then acetone hydantoin is synthesized with ethyl chloroacetate, and nitrofurantoin is obtained by condensation with 5-nitrofurfural diacetate after hydrolysis.
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