CAS number：123-39-7
molecular formula：C2H5NO
molecular weight：59.07
EINECS number：204-624-6

English synonyms

EK 7011;ek7011;Formamide,N-methyl-;Formylmethylamine;HCONHCH3;Methylformamide;Monomethylformamide;N-MENTHYL FORMAMID

Related categories

Pesticide intermediates; acaricide intermediates; nitrogen compounds; organic building blocks; amides/amide compounds; pharmaceutical intermediates; organic chemicals; amino acids and their derivatives; amides; amides; amineseries; Organicsolvents; chemical intermediates; organic intermediates Body; Amine; Chemical raw material; Organic chemical raw material; Chemical industry; 123-39-7; Organic raw material; Esters

Introduction

Pure N-methylformamide is a colorless transparent viscous liquid, m.p.-3.8°C, b.p.198°C, n25D 1.4310, relative density 0.9986 (25°C), soluble in water and inorganic salts, and has hygroscopicity. It is easy to decompose in acidic or alkaline solution.

Chemical properties

Pure N-methylformamide is a colorless transparent viscous liquid, m.p.-3.8°C, b.p.198°C, n25D 1.4310, relative density 0.9986 (25°C), soluble in water and inorganic salts, and has hygroscopicity. It is easy to decompose in acidic or alkaline solution.

Use

●  N-Methylformamide is an important raw material for organic synthesis. It is used in the synthesis of pesticides, insecticides and acaricides, monoformamidine and amitraz, and is also used in the production of medicine, synthetic leather, artificial leather, and as a solvent for chemical fiber textiles, etc. .

●  It is used as raw material for organic synthesis, for the synthesis of pesticides, insecticides, medicines, synthetic leather, artificial leather, etc.; and as a chemical fiber textile solvent.

●  N-Methylformamide is an important organic chemical raw material and intermediate. It is a kind of organic solvent with good performance. It is used to synthesize high-efficiency and low-toxic monomethylamide, dimethylamide, etc. It can be used as a reaction in organic synthesis Solvents and refined solvents are also widely used in medicine, dyes, spices and electrolysis, electroplating industries, etc.

Production method

●  1. The methylamine method is prepared by the reaction of methylamine and carbon monoxide. 2. The methyl formate method is obtained by the reaction of methyl formate and methylamine. 3. It is derived from the reaction of ethyl formate and methylamine. Add ethyl formate into the reactor, add methylamine aqueous solution under cooling, and reflux at 40°C for reaction. Then stand for 3d, and recover ethanol under reduced pressure to obtain the crude product. Then the finished product is obtained by vacuum distillation.

●  N-methylformamide mainly has the following three synthesis techniques. (1) The methylamine method is obtained by the action of methylamine and carbon monoxide. CO+CH3NH2→HCONHCH3 The mixture of monomethylamine 69.62% (mass fraction), methyl alcohol 29.87% (mass fraction) and sodium methylate 0.5% (mass fraction) (for monomethylamine is 0.72%) is supplied to reactor 87.05kg/ h, while supplying 56.5kg/h of carbon monoxide with a content of 99.5%, the reaction temperature is 90°C, and the pressure is 2.53MPa. Take out 140.75 kg of a mixture containing 80.5% (mass fraction) of monomethylamine per hour, that is, the amount of N-methylformamide produced is 113.4 kg per hour, and the production capacity of the 1L reactor is 1.89 kg of N-methylformamide per hour. (2) The methyl formate method is obtained by the reaction of methyl formate and methylamine. CH3NH2+HCOOCH3→HCONHCH3+CH3OH products are firstly distilled and rectified to obtain finished products, with a total yield of 90%; the product content is more than 95% to 99.5%. (3) The ethyl formate method is obtained by the action of ethyl formate and methylamine. HCOOC2H5+CH3NH2→HCONHCH3+C2H5OH First add ethyl formate to the reaction tank, then add methylamine aqueous solution under cooling [ethyl formate and methylamine aqueous solution are mixed according to 1:1.2 (mol)], reflux and stir at 40 ° C, and then Place it for 3 days, recover ethanol under reduced pressure, and distill the crude product under reduced pressure to obtain the finished product.

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