2-Bromo-4-methylaniline CAS 583-68-6
CAS number：583-68-6
molecular formula：C7H8BrN
molecular weight：186.05
EINECS number：209-515-7
English synonyms
2-bromo-4-methyl-benzenamin;2-Bromo-4-methylbenzenamine;2-Bromo-4-toluidine;2-bromo-p-toluidin;2-Bromo-4-methylaniline,99%(4-Amino-3-bromtoluol);2-Bromo-p-toluid;4-Amino-3-bromotoluene~2-Bromo-p-toluidine;2-Bromo-4-methylanline
Related categories
Anilines; pharmaceutical intermediates; benzene series; halides; chemical linkage; intermediates; chemical raw materials; chemical intermediates; organic intermediates; AromaticHydrocarbons (substituted) & Derivatives; Amines; blocks; Bromides;
Introduction
colorless liquid. The melting point is 26°C, the boiling point is 240°C, the relative density is 1.500, and the refractive index is 1.6020. Miscible with alcohol and ether, insoluble in water. Organic synthesis intermediates.
| Melting point | 14-16°C(lit.) |
| Boiling point | 240°C(lit.) |
| Density | 1.5g/mLat25°C(lit.) |
| Refractive index | n20/D1.602(lit.) |
| Flash point | >230°F |
| Storage conditions | Keep in dark place ,Inert atmosphere,Room temperature |
| Solubility | Chloroform(Slightly) |
| Shape | Oil |
| Acidity coefficient(pKa) | 2.97±0.10(Predicted) |
| Color | DarkYellowtoDarkBeige |
| Specific gravity | 1.500 |
| Water solubility | Insolubleinwater. |
| BRN | 1931711 |
| Stability | AirSensitive |
| InChIKey | UVRRJILIXQAAFK-UHFFFAOYSA-N |
| CAS database | 583-68-6(CASDataBaseReference) |
colorless liquid. The melting point is 26°C, the boiling point is 240°C, the relative density is 1.500, and the refractive index is 1.6020. Miscible with alcohol and ether, insoluble in water.
● Organic Synthesis Intermediates
● Heating p-toluidine and glacial acetic acid under reflux for 2 hours is converted into N-acetyl p-toluidine, cooled to 45°C, and bromine is added dropwise, and the bromination reaction is controlled at 50-55°C. The reactant was injected into an aqueous solution of sodium sulfite, and 3-bromo-4-acetamidotoluene was precipitated. Then it is hydrolyzed with concentrated hydrochloric acid, and the resulting hydrochloride reacts with sodium hydroxide solution to obtain free 2-bromo-4-methylaniline. Yield 51-57%.
