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      (1S)-(+)-Camphor-10-sulphonic acid CAS 3144-16-9

      • (1S)-(+)-Camphor-10-sulphonic acid CAS 3144-16-9...
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      Detailed introduction



      CAS number:3144-16-9
      molecular formula:C10H16O4S
      molecular weight:232.3
      EINECS number:221-554-1

      English synonyms

      D-CAMPHORSULFONIC ACID;D(-)-CAMPHORSULPHONIC ACID;D-CAMPHORSULPHONIC ACID;CSA;D-REYCHLER'S ACID;D-OXO-10-BORNANESULFONIC ACID;(+)-BETA-CAMPHORSULFONIC ACID;(+)-CAMPHOR-10-SULFONIC ACID

      Related categories

      Water environment treatment series; chemical reagents; intermediates; organic and printed electronics; asymmetric synthesis; amino acids; carbonyl compounds; chemical raw materials; carboxylic acids; organic raw materials; organic chemicals; pharmaceutical raw materials; flavors and fragrances; amino acids; chirality Building blocks; Phytochemistry; Biochemical reagents; Chiral products; API and intermediates of synthetic API; Traditional Chinese medicine reference substances; Biochemical reagents-amino acids; Other chemical products; Chiral Compounds;chiral;Bicyclic Monoterpenes;Biochemistry;for Resolution of Bases;Optical Resolution;Reagents for Oligosaccharide Synthesis;Synthetic Organic Chemistry;Terpenes;Peptide;Sulfur & Selenium Compounds;raw materials;chemical raw materials;chemical intermediate industrial raw materials;organic chemical raw materials ;food additives;daily chemicals;kit-Elisa kit;chemical reagents;chemical intermediates;reference substance;3144-16-9

      Introduction

      Optically active left-handed and right-handed camphorsulfonic acid is an important chiral isomer drug resolution agent. D-isomer can be obtained from natural camphor through bromination sulfonation, and can also be obtained from racemic camphorsulfonic acid by induced crystallization resolution.

      Chemical properties

      Melting point

      196-200 °C (dec.)(lit.)

      Specific optical rotation

      22 º (589nm, c=20, H2O 25 ºC)

      Boiling point

      344.46°C (rough estimate)

      Density

      1.2981 (rough estimate)

      Refractive index

      21.5 ° (C=5, H2O)

      Storage conditions

      Store below +30°C.

      Solubility

      Exhibit moderate solubility in HCCl.

      Shape

      Crystalline Powder

      Acidity coefficient(pKa)

      1.17±0.50(Predicted)

      Color

      White to off-white

      PH value

      0.3 (200g/l, H2O)

      Optical activity

      [α]20/D +21.5±1°, c = 10% in H2O

      Water solubility

      SOLUBLE

      Sensitive

      Hygroscopic

      Merck 

      14,1734

      BRN 

      2809675

      Stability

      Stable. Protect from moisture. Incompatible with strong oxidizing agents, strong bases.

      InChIKey

      MIOPJNTWMNEORI-GMSGAONNSA-N

      CAS database

      3144-16-9(CAS DataBase Reference)

      White crystal or crystalline powder, insoluble in ether, slightly soluble in glacial acetic acid and ethyl acetate, easy to deliquescence in humid air.

      Use

      ●  Organic synthesis intermediate, resolution agent.

      ●  It can be used as a resolving agent and a catalyst for dipeptide coupling.

      ●  Used for the separation of pharmaceutical intermediates or isomer products

      ●  for the pharmaceutical industry


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