(1S)-(+)-Camphor-10-sulphonic acid CAS 3144-16-9
CAS number：3144-16-9
molecular formula：C10H16O4S
molecular weight：232.3
EINECS number：221-554-1
English synonyms
D-CAMPHORSULFONIC ACID;D(-)-CAMPHORSULPHONIC ACID;D-CAMPHORSULPHONIC ACID;CSA;D-REYCHLER'S ACID;D-OXO-10-BORNANESULFONIC ACID;(+)-BETA-CAMPHORSULFONIC ACID;(+)-CAMPHOR-10-SULFONIC ACID
Related categories
Water environment treatment series; chemical reagents; intermediates; organic and printed electronics; asymmetric synthesis; amino acids; carbonyl compounds; chemical raw materials; carboxylic acids; organic raw materials; organic chemicals; pharmaceutical raw materials; flavors and fragrances; amino acids; chirality Building blocks; Phytochemistry; Biochemical reagents; Chiral products; API and intermediates of synthetic API; Traditional Chinese medicine reference substances; Biochemical reagents-amino acids; Other chemical products; Chiral Compounds;chiral;Bicyclic Monoterpenes;Biochemistry;for Resolution of Bases;Optical Resolution;Reagents for Oligosaccharide Synthesis;Synthetic Organic Chemistry;Terpenes;Peptide;Sulfur & Selenium Compounds;raw materials;chemical raw materials;chemical intermediate industrial raw materials;organic chemical raw materials ;food additives;daily chemicals;kit-Elisa kit;chemical reagents;chemical intermediates;reference substance;3144-16-9
Introduction
Optically active left-handed and right-handed camphorsulfonic acid is an important chiral isomer drug resolution agent. D-isomer can be obtained from natural camphor through bromination sulfonation, and can also be obtained from racemic camphorsulfonic acid by induced crystallization resolution.
Chemical properties
| Melting point | 196-200 °C (dec.)(lit.) |
| Specific optical rotation | 22 º (589nm, c=20, H2O 25 ºC) |
| Boiling point | 344.46°C (rough estimate) |
| Density | 1.2981 (rough estimate) |
| Refractive index | 21.5 ° (C=5, H2O) |
| Storage conditions | Store below +30°C. |
| Solubility | Exhibit moderate solubility in HCCl. |
Shape | Crystalline Powder |
| Acidity coefficient(pKa) | 1.17±0.50(Predicted) |
| Color | White to off-white |
| PH value | 0.3 (200g/l, H2O) |
Optical activity | [α]20/D +21.5±1°, c = 10% in H2O |
| Water solubility | SOLUBLE |
| Sensitive | Hygroscopic |
Merck | 14,1734 |
BRN | 2809675 |
| Stability | Stable. Protect from moisture. Incompatible with strong oxidizing agents, strong bases. |
InChIKey | MIOPJNTWMNEORI-GMSGAONNSA-N |
| CAS database | 3144-16-9(CAS DataBase Reference) |
White crystal or crystalline powder, insoluble in ether, slightly soluble in glacial acetic acid and ethyl acetate, easy to deliquescence in humid air.
Use
● Organic synthesis intermediate, resolution agent.
● It can be used as a resolving agent and a catalyst for dipeptide coupling.
● Used for the separation of pharmaceutical intermediates or isomer products
● for the pharmaceutical industry
