CAS number：98-92-0
molecular formula：C6H6N2O
molecular weight：122.12
EINECS number：202-713-4
NicotinamideForBiochemistry;NicotinamideB.P.,U.S.P.;Niacinamide/Nicotinamide;Nicotinamide(Niacinamide)Nicotinamide(Niacinamide)Bp/Usp;Nicotinamide,98%;Vitamin B3;Nicotinamidum;NIACINAMIDE USP GRANULAR
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Niacinamide, also known as nicotinamide, vitamin B3 or vitamin PP, is a water-soluble vitamin belonging to the B group vitamins. Nicotinic acid phosphate, NADP) components, the nicotinamide part of the two coenzyme structures in the human body has reversible hydrogenation and dehydrogenation properties, plays a role in hydrogen delivery in biological oxidation, can promote tissue respiration, biological oxidation Process and metabolism, important for maintaining the integrity of normal tissues, especially the skin, digestive tract and nervous system. When it is lacking, pellagra is caused due to the influence of cell respiration and metabolism, so this product is mainly used to prevent and treat pellagra, stomatitis, glossitis, etc.
| Melting point | 128-131 °C(lit.) |
| Boiling point | 150-160 °C |
| Density | 1.40 |
| Vapour density | 4.22 (vs air) |
| Vapor Pressure | 0Pa at 25℃ |
| Refractive index | 1.4660 (estimate) |
| Flash point | 182 °C |
| Storage conditions | 2-8°C |
| Solubility | 691g/l |
Shape | powder |
| Acidity coefficient(pKa) | 3.3(at 20℃) |
| Color | white |
Odor | Odorless |
| PH value | 6.0-7.5 (50g/l, H2O, 20℃) |
Acid-base indicator color change ph value range | 9 |
| Water solubility | 1000 g/L (20 ºC) |
Decomposition | >=200 °C |
Merck | 14,6523 |
BRN | 383619 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
InChIKey | DFPAKSUCGFBDDF-UHFFFAOYSA-N |
LogP | -0.38 at 21℃ |
| CAS database | 98-92-0(CAS DataBase Reference) |
● A kind of amide derivative of vitamin B3 and PARP inhibitor
● Vitamin medicine, involved in the metabolic process in the body, used to prevent and treat niacin deficiency such as pellagra
● Niacinamide has better water solubility than niacin, but it is easy to form complexes with vitamin C and agglomerate. Dosage 30-80mg/kg. Its use in skin care products can prevent skin roughness, maintain skin cell health, and promote skin whitening. Used in hair care, it can promote blood circulation in the scalp, healthy hair follicles, promote hair growth and prevent baldness.
● Biochemical research; nutrient composition of tissue culture medium; clinical medicine is vitamin B group, used for the prevention and treatment of pellagra, stomatitis, glossitis and other diseases.
● β-picoline is oxidized into nicotinic acid by air, which is obtained by reacting with ammonium hydroxide and then heating and dehydrating.
● Put nicotinic acid, boric acid and ammonia water into the reaction pot, feed ammonia gas under stirring, heat up and dissolve; then distill and recover ammonia, transfer it to a dehydration pot to continue to concentrate after reaching 120°C; start adding liquid ammonia when the temperature reaches 145°C, and Continue the ammonia reaction at 185-190°C for 20-30 hours. Then lower the temperature to 130°C, dilute with distilled water, add activated carbon, and decolorize with ammonia at 70-80°C for 2 hours; after the reaction, filter while it is hot, and cool the filtrate in water for 24 hours, separate and crystallize, wash with ethanol, and dry to obtain the finished product. Yield 89%.
● Put nicotinic acid, boric acid and ammonia water into the reaction pot, feed ammonia gas under stirring, raise the temperature to dissolve, then distill and recover ammonia, move it to dehydration pot to continue to concentrate after reaching 120°C, start adding liquid ammonia when the temperature reaches 145°C, and Continue the ammonia reaction at 185-190°C for 20-30h. Then lower the temperature to 130°C, dilute with distilled water, add activated carbon, and decolorize with ammonia at 70-80°C for 2 hours, filter while it is hot after the reaction, and cool the filtrate in water for 24 hours, separate and crystallize, wash with ethanol, and dry to obtain the finished product. 89%
● It is obtained by salting nicotinic acid and ammonia water and then dehydrating.
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