CAS number：1403-66-3
molecular formula：C60H123N15O21
molecular weight：1390.71
EINECS number：215-765-8

English synonyms

GENTAMYCINE;GentamysinsolutionforBiochemistry;Gentacycol;GENTAMICIN;GENTAMYCIN;Gentavet;GENTAMICINUM;Refobacin tm

Related categories

Aminoglycoside antibiotics; disinfection and sterilization; standard products; raw materials; API

Introduction

Gentamicin is a broad-spectrum antibiotic successfully developed independently in China, and it is one of the great scientific and technological achievements since the founding of New China. It began to be developed in 1967, and was successfully identified at the end of 1969. It was named "gentamicin", which means celebrating the "Nine National Congresses" and celebrating the greatness of the working class. Gentamicin [Gentamicin, gentamycin (gentamycin)] is extracted from the fermentation broth of Actinomycetes Monospore. It is an alkaline compound and is a commonly used aminoglycoside antibiotic. It is mainly used to treat bacterial infections, especially those caused by Gram-negative bacteria. Gentamicin is one of the few thermostable antibiotics, so it is widely used in media configuration.

●  Gentamicin is effective against Escherichia coli, Bacillus aerogenes, Klebsiella, Proteus mirabilis, certain indole-positive Proteus, Pseudomonas aeruginosa, certain Neisseria, certain non-pigmented Serratia and Chi Gram-negative bacteria such as Shigella have antibacterial effect. Among Gram-positive bacteria, Staphylococcus aureus (including β-lactamase-producing strains) is sensitive to this product; Streptococcus (including Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus faecalis, etc.) are all resistant to this product. Anaerobic bacteria (Bacteroides), Mycobacterium tuberculosis, Rickettsia, fungi and viruses are also resistant to this product. In recent years, due to the wide application of this product, drug-resistant strains have gradually increased, and the drug resistance rate of Pseudomonas aeruginosa, Klebsiella, Serratia and indox-positive Proteus to this product is very high. Gentamicin is mainly used for systemic or local infections caused by Gram-negative bacteria such as Escherichia coli, Shigella dysenteriae, Klebsiella pneumoniae, Proteus, and Pseudomonas aeruginosa (invalid for central infection).

●  Used to treat sepsis, urinary tract infections, staph infections, endocarditis, and other conditions

●  Aminoglycoside antibiotics to treat sepsis, urinary tract infections, staphylococcal infections, endocarditis, and other infections.

API Active Pharmaceutical Ingredients
Obtained from natural medicine. Natural medicine is an important part of medicine. For example, artemisinin, an effective antimalarial ingredient isolated from the traditional Chinese medicine Artemisia annua.
Take existing drugs as first-comers.
1) Discover the active ingredients of the drug from the side effects of the drug. For example, the phenothiazine antipsychotic chlorpromazine and its analogs are developed from the sedative side effects of the similarly structured antihistamine promethazine.
2) Obtained through drug metabolism research. For example, the metabolites of antidepressants imipramine and amitriptyline, norimipramine and noramitriptyline, have stronger antidepressant effects than the original drug; oxazepam is the active metabolite of diazepam.
3) Leading with existing breakthrough drugs. For example, the research on lansoprazole and other prazols is based on omeprazole, which is more active than omeprazole.
Obtained by screening with pharmacological model. Through combinatorial chemistry, a large number of chemical libraries with different structures are constructed without separation of mixtures. Through high-throughput screening, the components are found to have pharmaceutical activity and then separated, and the structure of the active compound is determined.
Designed according to physiological and pathological mechanisms. For example: the study of fluorouracil takes the nucleotide uracil synthesized from DNA or RNA as the lead compound, and replaces the hydrogen at position 5 with fluorine, making it a metabolic antagonist of the normal metabolites of the organism, and is used as an antitumor drug