Oxaliplatin CAS 61825-94-3
CAS number：61825-94-3
molecular formula：C8H12N2O4Pt
molecular weight：395.28
EINECS number：621-248-1
English synonyms
[SP-4-2-(1R-TRANS)]-(1,2-CYCLOHEXANEDIAMINE-N,N')[ETHANEDIOATA(2-)-O,O']PLATINUM;OXALIPLATIN;trans-l-diaminocyclohexane oxalatoplatinum;(1,2-cyclohexanediamine-n,n’)(ethanedioato(2-)-o,o’)-platinu(sp-4-2-(1r-tr;1-ohp;oxalato(1r,2r-cyclohexanediammine)platinum(ii);oxalatoplatin;[SP-4-2-(1R-trans)]-(1，2-Cyclohexanediamine-N，N，)[ethanedioato(2-)-O，O’Jplatinum
Related categories
Anti-tumor drugs; Other anti-tumor drugs; Drugs; Cell signaling and neurobiology; Pharmaceutical raw materials for anti-cancer; Small molecule inhibitors, natural products; Anti-tumor; Drugs and immunosuppressants; intermediates; pharmaceutical raw materials; small molecule inhibitors; other biochemical reagents; medical raw materials; cell biology reagents; medical raw materials; pharmaceutical raw materials; intermediates; biochemical industry; pharmaceutical, pesticide and dye intermediates body; chemical raw material;
Pharmaceutical material and intermeidates;Active Pharmaceutical Ingredients;Antineoplastic;Intermediates & Fine Chemicals;Pharmaceuticals;APIs;Amines;Heterocycles;chemical reaction,pharm,electronic,materials;PRAXILENE;Inhibitors;raw materials;API;chemical reagents
Introduction
Oxaliplatin, also known as oxatine and oxaliplatin, belongs to platinum derivatives. It is clinically used to treat patients with metastatic colorectal cancer after failure of fluorouracil treatment. It can be used alone or in combination with fluorouracil. , Carboplatin is the third-generation new platinum anti-tumor compound, and it is also the only platinum-based drug with significant activity against colorectal cancer so far. The principle of action is to act on DNA by producing alkylated conjugates, forming intra-strand and inter-strand crosslinks to inhibit DNA synthesis and replication. At the same time, it also inhibits the proliferation of ovarian cancer and melanoma cell lines
Chemical properties
Specific optical rotation | +74.5-78.0 (D/20)(c=0.5,H2O) |
| Storage conditions | 2-8°C |
| Solubility | Slightly soluble in water, very slightly soluble in methanol, practically insoluble in anhydrous ethanol. |
| Shape | solid |
| Color | White to Almost white |
Water solubility | Soluble in water with heating and/or sonication |
Merck | 14,6912 |
| Stability | Stable. Store cool. Incompatible with oxidizing agents. |
InChIKey | ZROHGHOFXNOHSO-BNTLRKBRSA-L |
| CAS database | 61825-94-3 |
Use
● For the treatment of colorectal cancer.
● Antineoplastic agent, used to treat colorectal cancer
Production method
● 5g trans-cyclohexanediamine and 18g K2 (PtCl4) aqueous solution were reacted at room temperature for 12h to obtain 12g of intermediate product (I). 6: Add 8 g of silver nitrate to 3 g of compound (I) in water,
and stir for 2 to 3 h in the dark, then add 4.8 g of dipotassium oxalate, and react at room temperature for 8 h to obtain oxaliplatin.
