CAS number：863127-77-9
molecular formula：C22H28ClN7O3S
molecular weight：506.02
EINECS number：638-874-6

English synonyms

Dasatinib R;BMS-354825 Monohydrate;N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide hydrate;Dasatinib monohydrate N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide monohydrate;Dasatinib monohydrate, >=99%;dasatinib monohydrate;5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-, hydrate (1:1);n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-

Related categories

TINIBS products (Anti-cancer); pharmaceutical carcinogenic kinase inhibitors; pharmaceutical intermediates; intermediates; raw materials; small molecule inhibitors, natural products; anti-leukemia; pharmaceutical raw materials;
Molecular Targeted Antineoplastic;API;SPRYCEL;Anti-cancer&immunity;
Dasatinib; pharmaceutical raw materials; anti-cancer; small molecule inhibitors; Inhibitors; organic optoelectronics; medical raw materials; chemical reagents; chemical intermediates; raw materials and intermediates; chemical raw materials; anti-tumor; Pharmaceutical

Introduction

Dasatinib, also known as DASA tin IB, is an off-white to yellow solid chemical. Dasatinib is an antineoplastic drug, clinically mainly used for the treatment of chronic phase, accelerated phase and blast phase of Philadelphia chromosome positive (Ph+) chronic myeloid leukemia (CML) resistant to or intolerant of imatinib mesylate (acute myeloid and lymphocytic) adult patients.

Chemical properties

Use

●  Anticancer raw material drug intermediates/pharmaceutical intermediates

●  Dasatinib is used in all stages of chronic myelogenous leukemia (chronic phase, accelerated phase, lymphoid cell blast phase and myeloid blast phase) in adult patients. At the same time, the FDA also approved dasatinib through normal procedures for the treatment of adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia who are resistant or intolerant to other therapies.

Production method

API Active Pharmaceutical Ingredients
Obtained from natural medicine. Natural medicine is an important part of medicine. For example, artemisinin, an effective antimalarial ingredient isolated from the traditional Chinese medicine Artemisia annua.
Take existing drugs as first-comers.
1) Discover the active ingredients of the drug from the side effects of the drug. For example, the phenothiazine antipsychotic chlorpromazine and its analogs are developed from the sedative side effects of the similarly structured antihistamine promethazine.
2) Obtained through drug metabolism research. For example, the metabolites of antidepressants imipramine and amitriptyline, norimipramine and noramitriptyline, have stronger antidepressant effects than the original drug; oxazepam is the active metabolite of diazepam.
3) Leading with existing breakthrough drugs. For example, the research on lansoprazole and other prazols is based on omeprazole, which is more active than omeprazole.
Obtained by screening with pharmacological model. Through combinatorial chemistry, a large number of chemical libraries with different structures are constructed without separation of mixtures. Through high-throughput screening, the components are found to have pharmaceutical activity and then separated, and the structure of the active compound is determined.
Designed according to physiological and pathological mechanisms. For example: the study of fluorouracil takes the nucleotide uracil synthesized from DNA or RNA as the lead compound, and replaces the hydrogen at position 5 with fluorine, making it a metabolic antagonist of the normal metabolites of the organism, and is used as an antitumor drug