CAS number：1421373-66-1
molecular formula：C28H33N7O2.CH4O3S
molecular weight：595.71298
EINECS number：200-064-1

English synonyms

AZD-9291 (Mesylate);N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide methanesulfonate (1:1);AZD-9291 mesylate N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide methanesulfonate (1:1);Osimertinib;N-[2-(2-dimethylaminoethylmethylamino)-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide mesylate salt;Osimertinib Mesylate(AZD9291);Osimertinib mesylate;Mereletinib mesylate

Related categories

Inhibitors; compounds; fine chemicals; pharmaceutical raw materials; pharmaceutical intermediates; raw materials; lung cancer; anti-tumor; AZD09; pharmaceutical raw materials - scientific research materials; reference substances - impurity reference substances; API; cell biology reagents; other; medical raw materials ;API-API;Osimertinib synthetic raw material AZD9291;chemical raw materials;conventional products;anti-tumor;chemical reagents;

Introduction

AZD9291 (methanesulfonate) is osimertinib mesylate, this product is suitable for disease progression during or after previous epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy, and has been detected Treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) confirmed to have EGFR T790M mutation-positive disease. AZD9291 (methanesulfonate) is highly selective, with IC50s of 11.4 nM and 12.9 nM for T790M/L858R mutation and exon 19 deletion EGFR, respectively, while its inhibitory activity against wild-type EGFR (IC50) is 494 nM. Osimertinib is an irreversible inhibitor of EGFR and can form covalent bonds with molecular targets, so theoretically the response lasts longer and the chance of drug resistance is reduced accordingly.

Active Pharmaceutical Ingredients

API, also known as active pharmaceutical ingredients, refers to any substance or mixture of substances used in the manufacture of drugs. Such substances are used in the diagnosis, treatment, symptom relief, treatment or prevention of diseases. It has pharmacological activity or other direct effects or can affect the function or structure of the body. API meaning pharma.

●  N-(4-N-(4- Fluoro-2-methoxy-5-nitrobenzene)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine followed by N,N,N'-trimethyl Ethylenediamine replaces fluorine, and then reduces the nitro group with ferric ammonium, then reacts with 3-chloropropionyl chloride and eliminates the reaction to obtain AZD9291, the reaction yield is 17.5%. AZD9291 was prepared by salt formation with methanesulfonic acid to obtain AZD9291 (methanesulfonate).