CAS number：105-56-6
molecular formula：C5H7NO2
molecular weight：113.11
EINECS number：203-309-0

English synonyms

2-cyano-aceticacidethylester;Acetic acid,2-cyano-, ethyl ester;Aceticacid,cyano-,ethylester;Cyanacetate ethyle;cyanacetateethyle;ethylcyanacetate;Ethylcyanoacetat;Ethylester kyseliny kyanoctove

Related categories

Herbicide intermediates; sulfonylurea herbicides; pesticide intermediates; analytical standards; esters; organic synthesis; pharmaceutical intermediates; organic chemical raw materials; inorganic acids; impurity reference substances

Chemical properties

Colorless or light yellow liquid. There is an aromatic smell. not soluble in water. Miscible with ethanol and ether. Soluble in ammonia water and strong alkaline aqueous solution.

Use

●  It is used as a pharmaceutical intermediate, used for caffeine and vitamin B, and also used as an oil-soluble coupler for color film and a raw material for 502 adhesive

●  Ethyl cyanoacetate is an intermediate for the preparation of diethyl malonate, from which 2-amino-4,6-dimethoxypyrimidine can be prepared as an intermediate for sulfonylurea herbicides, and also for the insecticide fluoride The intermediate of nitrile can also be used as the intermediate of medical vitamin B.

●  This product is an intermediate of fine chemical products such as medicine and dyestuff, and is used to synthesize esters, amides, acids and nitriles. In Japan, it is mainly used as an intermediate of cyanoacrylate quick-drying adhesives, used in the bonding of auto parts and household appliances assemblies, and also used in vitamin B6, synthetic dyes and other fields. The cyclization of ethyl cyanoacetate with methoxyacetylacetone and ammonia can produce 5-cyano-6-hydroxy-4-methoxymethyl-2-picoline. After nitration, chlorination and catalytic hydrogenation, 3-amino-5-aminomethyl-4-methoxymethyl-2-picoline can be obtained. Further diazotization, hydrolysis, and salt formation can obtain vitamin B6.

●  Used in organic synthesis, pharmaceutical industry, dye industry.

Production method

●  Chloroacetate esterification cyanation method: Chloroacetic acid and ethanol are subjected to esterification reaction to generate ethyl chloroacetate, and the refined ethyl chloroacetate is subjected to cyanation reaction with sodium cyanide to obtain crude ethyl cyanoacetate , and then filtered, distilled under normal pressure and rectified under reduced pressure to obtain fine ethyl cyanoacetate.

●  Chloroacetic acid cyanation esterification method: Chloroacetic acid is neutralized with soda ash to generate sodium chloroacetate, then reacted with sodium cyanide to obtain sodium cyanoacetate, then acidified with hydrochloric acid to obtain cyanoacetic acid, and finally esterified with ethanol to obtain ethyl cyanoacetate Esters are obtained by filtration, atmospheric distillation and vacuum distillation.

●   The cyanoacetic acid esterification method is obtained by esterifying cyanoacetic acid and ethanol.

●  Its preparation method is derived from the action of cyanoacetic acid and ethanol. Add cyanoacetic acid, ethanol and catalyst sulfuric acid into the reactor to reflux for 3 hours, cool down to 10°C, wash with water, separate layers, dry, and distill under reduced pressure to obtain the finished product.
NCCH2COOH+C2H5OH[H2SO4]→NCCH2COOC2H5+H2O

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