CAS number：3473-63-0
molecular formula：C3H8N2O2
molecular weight：104.11
EINECS number：222-442-5

English synonyms

Methanimidamide(9CI);ormamidine acetate;IMINOFORMAMIDE ACETATE;FORMAMIDINE ACETATE SALT;FORMAMIDINE,ACETIC ACID;FORMAMIDINE ACETIC ACID SALT;FORMAMIDINE ACETATE;FAA

Related categories

Imines; raw materials; imides; amidines; pharmaceutical raw materials; amidines; pharmaceutical intermediates; organic building blocks; carbonyl compounds; standard products; chemical raw materials; chemical reagents; other chemical products; biochemical reagents-other chemical reagents; Basic raw materials; agricultural and veterinary raw materials; raw materials; pharmaceutical raw materials; chemical intermediates industrial raw materials; organic chemical raw materials; chemical intermediates; general biochemical reagents - organic acids; fine chemical raw materials; Zhishang chemical intermediates; Pharmaceutical Intermediates; API; chemical additives

 Chemical properties

White crystals. The melting point is 162-164°C.

Use

●  For the synthesis of 4-hydroxyl-5-fluoropyrimidine.

●  Methyridine acetate is mainly used for the synthesis of a class of compounds with biological activity, such as the antineoplastic drug 4-hydroxy-5-fluoropyrimidine, and can also be used for the synthesis of cyclohexapeptide antifungal drugs, and the synthesis of trichloropyrimidine, etc.

Production method

●  From the condensation of triethyl orthoformate and glacial acetic acid through ammonia. Add triethyl orthoformate to glacial acetic acid and heat, and react with ammonia for 1.5h, and white crystals are precipitated, and then continue to pass ammonia for half an hour. The reactant is firstly distilled at atmospheric pressure, and then the alcohol is evaporated to the fullest by distillation under reduced pressure. Cool to 25°C, wash with absolute ethanol, filter, and dry to obtain formamidine acetate.

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