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Tris(hydroxymethyl)aminomethane, commonly known as Tris or THAM, is a highly versatile organic compound widely used as a biological buffer, pH regulator, and intermediate in various chemical formulations. With excellent buffering capacity in the pH 7.0–9.0 range, Tris is a standard component in biochemical research, molecular biology, pharmaceuticals, cosmetics, and industrial applications. It is known for its high purity, low toxicity, and stable performance.
| Item | Details |
| Product Name | Tris(hydroxymethyl)aminomethane |
| Short Name | Tris / THAM |
| CAS Number | 77-86-1 |
| Molecular Formula | C₄H₁₁NO₃ |
| Molecular Weight | 121.14 |
| Appearance | White crystalline powder or flakes |
| Purity | ≥ 99% (Industrial/Biochemical/Pharma Grade available) |
| pH (1% solution) | 10.0–11.5 |
| Melting Point | 168–172 °C |
| Solubility | Freely soluble in water and ethanol |
| Stability | Stable under normal conditions; avoid strong oxidizers |
| Applications | Buffering agent, pharmaceutical excipient, cosmetic raw material, laboratory reagent |
| Packaging | 25kg bags/drums or customized |
Excellent pH buffering capacity (pKa ~ 8.1 at 25°C)
Low toxicity & suitable for biochemical use
High-water solubility and stable performance
Compatible with a wide range of solvents and formulations
Available in industrial, cosmetic, and pharmaceutical grades
1. Biochemical Research
Widely used buffer component in electrophoresis, protein purification, nucleic acid extraction, and cell culture.
2. Pharmaceutical Industry
Used as a pH regulator and excipient in injectable drugs
Employed in formulations of local anesthetics and biological preparations
3. Cosmetics & Personal Care
Maintain product stability and pH balance
Used in lotions, creams, and cleansing products
4. Industrial Applications
Intermediate for surfactants
Useful in electroplating, textile, and coating additives
Acts as a neutralizing agent in chemical synthesis
1. What is the main function of Tris?
Tris is primarily used as a buffering agent to maintain stable pH conditions in biochemical and industrial processes.
2. Is Tris safe for cosmetic use?
Yes. With low irritation and high compatibility, Tris is used to adjust and stabilize pH in creams, lotions, and cleansing products.
3. Can Tris be used in pharmaceutical formulations?
Yes. Pharmaceutical-grade Tris is widely used as an excipient and pH regulator in injections and biological products.
4. What is its solubility in water?
Tris dissolves easily in water, forming a clear solution suitable for buffer preparation.
5. Do you provide COA, TDS, and MSDS?
Yes, full documentation including COA, MSDS, and technical data sheets can be provided.
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