CAS number：144060-53-7
molecular formula：C16H16N2O3S
molecular weight：316.37
EINECS number：682-158-6

English synonyms

Febuxostat (Uloric);FBX;Uloric;Febuxostat (TEI-6720);Febuxostat Tablets;FEBUXOSTAT API;Febuxostat (This product is unavailable in the U.S.);Febuxostat Tabletshehe

Related categories

Impurity reference substances; fine chemicals; intermediates and fine chemicals, pharmaceuticals; inhibitors; heterocyclic compounds; febuxostat intermediates; pharmaceutical intermediates; febuxostat original drug; febuxostat; febuxostat; Pharmaceutical raw materials; intermediates; raw materials (API); raw materials; cardiovascular and cerebrovascular drugs; small molecule inhibitors; anti-gout drugs; endocrine and metabolic systems; pharmaceutical and chemical industries; ;Chemicals;Medical Raw Materials;
Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API;Zjh;API;Febuxostat;TRILIPIX;Other APIs;eterocycles;
Antipyretic and analgesic products; febuxostat impurities; organic raw materials; compounds; drug impurities and intermediates; pharmaceutical raw materials; Raw materials; anti-inflammatory; chemical reagents; chemical intermediates; chemical industry; chemical raw materials

Introduction

Febuxostat (febuxostat) is a new generation of xanthine oxidase inhibitor developed by Teijin Corporation. It is clinically used to treat hyperuricemia (gout). Its structure is similar to that of the xanthine oxidase inhibitor drug developed 40 years ago. Completely different, it is a new and highly effective selective inhibitor of non-purine xanthine oxidase. Xanthine oxidase is a key enzyme that promotes uric acid production. Febuxostat can reduce the level of uric acid in the blood of patients with hyperuricemia gout. Clinical studies have shown that this product is safe and effective. This product is metabolized by the liver and does not depend on renal excretion. Patients do not require dose reduction. The dose is 40 mg or 80 mg once a day, and it is not recommended for the treatment of gout patients without hyperuricemia.

Treatment of Hyperuricemia (Gout)

A xanthine oxidase and xanthine dehydrogenase inhibitor.

API Active Pharmaceutical Ingredients

Obtained from natural medicine. Natural medicine is an important part of medicine. For example, artemisinin, an effective antimalarial ingredient isolated from the traditional Chinese medicine Artemisia annua.

Take existing drugs as first-comers.
1) Discover the active ingredients of the drug from the side effects of the drug. For example, the phenothiazine antipsychotic chlorpromazine and its analogs are developed from the sedative side effects of the similarly structured antihistamine promethazine.
2) Obtained through drug metabolism research. For example, the metabolites of antidepressants imipramine and amitriptyline, norimipramine and noramitriptyline, have stronger antidepressant effects than the original drug; oxazepam is the active metabolite of diazepam.
3) Leading with existing breakthrough drugs. For example, the research on lansoprazole and other prazols is based on omeprazole, which is more active than omeprazole.
Obtained by screening with pharmacological model. Through combinatorial chemistry, a large number of chemical libraries with different structures are constructed without separation of mixtures. Through high-throughput screening, the components are found to have pharmaceutical activity and then separated, and the structure of the active compound is determined.
Designed according to physiological and pathological mechanisms. For example: the study of fluorouracil takes the nucleotide uracil synthesized from DNA or RNA as the lead compound, and replaces the hydrogen at position 5 with fluorine, making it a metabolic antagonist of the normal metabolites of the organism, and is used as an antitumor drug