CAS number：55297-96-6
molecular formula：C32H51NO8S
molecular weight：609.82
EINECS number：259-581-6

English synonyms

((2-(DIETHYLAMINO)ETHYL)THIO)ACETIC ACID 8-ESTER WITH (3AS,4R,5S,6S,8R,9R,9AR,10R)-OCTAHYDRO-5,8-DIHYDROXY-4,6,9,10-TETRAMETHYL-6-VINYL-3A,9-PROPANO-3AH-CYCLOPENTACYCLOOCTEN-1(4H)-ONE FUMARATE;sq22947;ter,(e)-2-butenedioate(1:1)(salt);thiamutilinfumarate;STAMULIN;TIAMULIN FUMARATE;TIAMULIN FUMERATE;TIAMULIN HYDROGEN FUMARATE

Related categories

Antibiotics; veterinary drugs; microbial metabolites; tiamulin fumarate; chemical industry; food additives; pharmaceutical raw materials; veterinary drug raw materials; raw materials; intermediates; - API; API API; Veterinary API; Veterinary Drug API; Medical API; Raw Materials; Chemical Raw Materials; Feed Additives; Chemical Reagents; Amines; Heterocycles; Intermediates & Fine Chemicals; ;Chemical reagents-veterinary raw materials;biochemical reagents;others;scientific research raw materials;veterinary raw materials;industrialization

Introduction

Tiamulin fumarate is a bacteriostatic antibiotic belonging to the pleuromutilin class. It is a derivative of pleuromutilin, but it also has a bactericidal effect on sensitive bacteria at very high concentrations. Like macrolide antibiotics, tiamulin fumarate also inhibits bacterial protein synthesis by binding to the ribosomal 50S subunit. This product has good antibacterial activity against a variety of Gram-positive bacteria, including most staphylococci and streptococci (except group D streptococci), various mycoplasmas and Treponema hyodysenteriae.

●  Tiamulin fumarate can be used to treat swine pneumonia caused by Actinobacillus pleuropneumoniae and swine dysentery caused by Treponema hyodysenteriae. As a feed drug additive for pigs, it can promote weight gain. It is also effective for chicken chronic respiratory disease, swine mycoplasma pneumonia and chicken staphylococcus synovitis.

●  Tiamulin fumarate is a bacteriostatic antibiotic belonging to the pleuromutilin class, but it also has a bactericidal effect on sensitive bacteria at very high concentrations. Like macrolide antibiotics, tiamulin fumarate also inhibits bacterial protein synthesis by binding to the ribosomal 50S subunit. This product has good antibacterial activity against a variety of Gram-positive bacteria, including most staphylococci and streptococci (except group D streptococci), various mycoplasmas and Treponema hyodysenteriae. This product is compatible with aureomycin at a ratio of 1:4, which can treat pig bacterial enteritis, bacterial pneumonia, treponemal swine dysentery, and treat mycoplasma pneumonia, Bordetella bronchiseptica and Pasteurella multocida mixed infection. Pneumonia caused by significant curative effect.

API Active Pharmaceutical Ingredients
Obtained from natural medicine. Natural medicine is an important part of medicine. For example, artemisinin, an effective antimalarial ingredient isolated from the traditional Chinese medicine Artemisia annua.
Take existing drugs as first-comers.
1) Discover the active ingredients of the drug from the side effects of the drug. For example, the phenothiazine antipsychotic chlorpromazine and its analogs are developed from the sedative side effects of the similarly structured antihistamine promethazine.
2) Obtained through drug metabolism research. For example, the metabolites of antidepressants imipramine and amitriptyline, norimipramine and noramitriptyline, have stronger antidepressant effects than the original drug; oxazepam is the active metabolite of diazepam.
3) Leading with existing breakthrough drugs. For example, the research on lansoprazole and other prazols is based on omeprazole, which is more active than omeprazole.
Obtained by screening with pharmacological model. Through combinatorial chemistry, a large number of chemical libraries with different structures are constructed without separation of mixtures. Through high-throughput screening, the components are found to have pharmaceutical activity and then separated, and the structure of the active compound is determined.
Designed according to physiological and pathological mechanisms. For example: the study of fluorouracil takes the nucleotide uracil synthesized from DNA or RNA as the lead compound, and replaces the hydrogen at position 5 with fluorine, making it a metabolic antagonist of the normal metabolites of the organism, and is used as an antitumor drug