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Grubbs Catalyst 2nd Generation (CAS 246047-72-3) is a highly efficient ruthenium-based metathesis catalyst widely used in ring-opening metathesis polymerization (ROMP), ring-closing metathesis (RCM), cross-metathesis (CM), and various olefin metathesis reactions.
It features excellent stability, high functional group tolerance, and outstanding catalytic efficiency, making it ideal for pharmaceutical synthesis, polymer R&D, fine chemicals, and specialty materials production.This second-generation catalyst delivers faster reaction rates and broader substrate compatibility compared to the first-generation Grubbs catalyst.
| Item | Description |
| Product Name | Grubbs Catalyst 2nd Generation |
| CAS Number | 246047-72-3 |
| Molecular Formula | C₄₆H₆₅Cl₂N₂O₂PRu |
| Molecular Weight | 848.95 g/mol |
| Appearance | Dark purple solid / crystalline |
| Purity | ≥98% (customized grades available) |
| Melting Point | ~150–155°C (decomposition) |
| Solubility | Soluble in DCM, THF, toluene, benzene, chloroform |
| Storage | Store under inert gas (argon/nitrogen), dry and cool conditions |
| Packing | 1g / 5g / 10g / customized inert-sealed bottles |
| Test Item | Specification |
| Appearance | Dark purple solid |
| Purity (HPLC) | ≥98.0% |
| Ru Content | Conforms |
| Chloride Content | Conforms |
| Residue on Ignition | ≤0.2% |
| Moisture (KF) | ≤0.1% |
✔ Excellent stability in air and moisture compared to other metathesis catalysts
✔ High catalytic activity and functional group tolerance
✔ Suitable for a wide range of olefin metathesis reactions
✔ Ideal for lab-scale and industrial production
✔ Faster kinetics than 1st generation catalysts
Store in tightly sealed inert gas conditions (N₂ or Ar).
Keep away from moisture, light, and heat.
Recommended storage temperature: 2–8°C.
Highly sensitive to air and moisture; handle quickly under inert atmosphere.
Use gloves and protective equipment during operation.
Q1: What is Grubbs Catalyst 2nd Generation mainly used for?
It is mainly applied in ROMP, RCM, and cross-metathesis reactions for pharmaceuticals, polymers, and specialty chemicals.
Q2: How stable is the catalyst?
It is more stable than most metathesis catalysts but still sensitive to moisture and air; it should be handled under inert gas.
Q3: Can it be used at industrial scale?
Yes. It is widely used in industrial macrocycle synthesis and polymer production.
Q4: What solvents can dissolve this catalyst?
DCM, chloroform, benzene, toluene, and THF.
Q5: Do you offer custom purity or bulk orders?
Yes, bulk supply and customized specifications are available.
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