CAS number：111-01-3
molecular formula：C30H62
molecular weight：422.81
EINECS number：203-825-6

English synonyms

2,6,10,15,19,23-hexamethyl-tetracosan;2,6,10,15,19,23-hexamethyltetra-cosane,(squalane);Dermane;Dodecahydrosqualene;Tetracosane,2,6,10,Chemicalbook15,19,23-hexamethyl-,(all-E)-;SQUALANE,FORGC;SQUALANE,1000MG,NEAT;2,6,10,15,19,23-Hexamethyltetracosane,Cosbiol,Perhydrosqualene,Robane

Related categories

Biochemical Reagents-Other Chemical Reagents;Organic Chemical Raw Materials;Organic Raw Materials;Chemical Products-Organic Chemicals;Biochemical Reagents;Cosmetic Raw Materials;Natural Plant Essential Oils;General Reagents;;Acyclic;Alkanes;organic building blocks;plant extracts;alkanes;organic chemicals;raw materials;daily chemical raw materials;chemical materials;biochemicals;monomer fragrances;vegetable base oils;chemical raw materials;anti-aging and anti-oxidation;vegetable oils;cosmetics ;Biochemistry;Terpenes;TerpenesChemicalbook(Others);GasChromatography;PackedGC;StationaryPhases;BuildingBlocks;ChemicalSynthesis;OrganicBuildingBlocks;111-01-3

Introduction

Squalane is an important component of human sebum. The sebum secreted by the sebaceous glands of human skin contains about 10% squalene and 2.4% squalane. The human body converts squalene into squalane. Squalene can provide oxygen and nutrients to cells, and can promote cell metabolism, form a sebum film on the outer layer of the skin, prevent moisture loss, and isolate bacteria, dust and ultraviolet damage. However, the secretion of squalene in women will drop sharply from around the age of 5, and the skin will be dehydrated, slack, dull, and aging. Therefore, it is very important to supplement the skin with squalane! The cosmetic effects of squalene and squalane are almost the same, but the molecular structure of squalene is unstable and easily oxidized, so it is generally wrapped in capsules and suitable for oral administration; while squalane is a stable pure oil, Suitable for external use.Squalane has good permeability and can enter the inside of the skin, replenish cell lipids, and nourish the skin. After massaging the skin with squalane, the skin will become soft, moisturized and elastic, which is the result of the penetration of squalane into the skin. Squalane will form a breathable and water-permeable protective film on the surface of the skin. The advantage is that it is not heavy, but it is moderately moisturizing. In particularly dry and cold seasons, if only squalane is used, the water-locking ability is not enough, and it needs to be used in conjunction with other products.
 

Refined squalane is a colorless, tasteless, odorless, inert transparent oily viscous liquid. Slightly soluble in methanol, ethanol, acetone and glacial acetic acid, can be mixed with benzene, chloroform, carbon tetrachloride, petroleum ether, ether, mineral oil and other animal and vegetable oils. Relative density (15°/4°C) 0.812, refractive index (15°C) 1.4530, iodine value 0～5, saponification value 0～5, acid value 0～0Chemicalbook.2, freezing point -38°C, boiling point 350°C. Stable in the air, will slowly oxidize under the action of sunlight. The sebaceous glands can synthesize squalene, sebum contains squalene, the sebum content of children is 1%, the sebum content of adults is 10%, and the sebum content of squalane is about 2%. Its permeability, lubricity and air permeability are better than other oils and match with most cosmetic raw materials.

Use

Squalane is a kind of hydrocarbon oil obtained by hydrogenation of squalene extracted from deep-sea shark liver, so it is also known as deep-sea shark liver oil. Scientific research has found that squalane is a rare animal oil with high chemical stability and excellent use feeling. It has good affinity for the skin, low polarity and moderate spreadability.

●   Squalane: Strengthen the repair of the epidermis, effectively form a natural protective film, and help the balance between the skin and sebum.

●   Squalane is a kind of lipid closest to human Chemicalbook body sebum. It has a strong affinity and can be integrated with the human sebum membrane to form a natural barrier on the skin surface.

●   Squalane can also inhibit the peroxidation of skin lipids, can effectively penetrate into the skin, and promote the proliferation of skin basal cells, which has obvious physiological effects on delaying skin aging, improving and eliminating melasma.

●  Squalane can also open skin pores, promote blood microcirculation, increase cell metabolism, and help repair damaged cells.

●  Used as a stationary solution for gas chromatography

Production method

①It is directly extracted from cod liver oil. During the extraction, crude squalane is obtained by vacuum distillation first, and then under the action of nickel catalyst, hydrogenation at high temperature and high pressure is carried out to remove the double bond part, and then vacuum distillation can be obtained.

② synthesis method. Using isoprene as raw material, firstly chlorinate isoprene to generate methyl heptenone, then make dehydrolinalol, and then make linalol, and then pass through geranyl acetone, and finally generate horn. Squalane Chemicalbook.

③Using squalene as raw material, it is obtained by direct hydrogenation.

④Using olive oil as raw material, extracting and separating squalene from it, and then hydrogenating it, it can be obtained.

⑤ Linalol reacts with ethyl acetoacetate to generate 3,7,11-trimethyldodecane-6,10-dien-1-yn-3-ol, which is then oxidized with cuprous oxide as a catalyst And coupling, hydrogenation, squalane products can be obtained.

●  Squalane is produced by hydrogenating squalene. Squalene exists in blue whale and shark liver, which can be obtained by extraction, and then refined to obtain squalene.

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