CAS number：81110-73-8
molecular formula：C21H23NO4S
molecular weight：385.48
EINECS number：688-010-7

English synonyms

ACETORPHAN;RACECADOTRIL;n-[2-[(acetylthio)methyl]-1-oxo-3-phenylpropyl]-glycine phenylmethyl ester;Redotil;Benzyl 2-(3-(acetylthio)-2-benzylpropanaMido)acetate;Racecadotril, 98%, a potent enkephalinase inhibitor;(RS)-Benzyl N-[3-(acetylthio)-2-benzylpropanoyl]glycinate;Cadotril

Related categories

Organic raw materials; nerve signals; antifungal drugs; small molecule inhibitors; antidiarrheal drugs; pharmaceutical raw materials; Drug impurities and intermediates; pharmaceutical raw materials; raw materials; pharmaceutical and chemical raw materials; chemical reagents; digestion; medical raw materials; fine chemical products; daily chemicals;
Antidiarrheal;Pharmaceutical Intermediates;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Pharmaceutical raw material

Introduction

Racecadotril, also known as acetorphan, fenghaiting, Ledu, dulabo, is an antidiarrheal drug with a new mechanism of action, which directly inhibits excessive intestinal secretion, quickly improves diarrhea symptoms, and treats diarrhea in children. Viral diarrhea has a remarkable curative effect, can significantly shorten the course of the disease, and reduce the pain of children. It is suitable for acute diarrhea in adults and infants and children over 1 month old. It was first successfully developed by the French company Bioprojet. It was first launched in France in 1993 under the trade name Tiorfan was launched, and shortly after it was launched, the Canadian Pediatric Association and the US Centers for Disease Control and Prevention (CDC) listed racecadotril as an essential drug for the treatment of children with diarrhea. In 2011, it was also included in the recommendation of the Chinese National Pediatric Diarrhea Treatment Consensus medication. At present, domestic front-line pediatricians have regarded racecadotril as an efficient and safe drug for the clinical treatment of children with diarrhea.

Active Pharmaceutical Ingredients
API, also known as active pharmaceutical ingredients, refers to any substance or mixture of substances used in the manufacture of drugs. Such substances are used in the diagnosis, treatment, symptom relief, treatment or prevention of diseases. It has pharmacological activity or other direct effects or can affect the function or structure of the body. API meaning pharma.

API Active Pharmaceutical Ingredients
Obtained from natural medicine. Natural medicine is an important part of medicine. For example, artemisinin, an effective antimalarial ingredient isolated from the traditional Chinese medicine Artemisia annua.
Take existing drugs as first-comers.
1) Discover the active ingredients of the drug from the side effects of the drug. For example, the phenothiazine antipsychotic chlorpromazine and its analogs are developed from the sedative side effects of the similarly structured antihistamine promethazine.
2) Obtained through drug metabolism research. For example, the metabolites of antidepressants imipramine and amitriptyline, norimipramine and noramitriptyline, have stronger antidepressant effects than the original drug; oxazepam is the active metabolite of diazepam.
3) Leading with existing breakthrough drugs. For example, the research on lansoprazole and other prazols is based on omeprazole, which is more active than omeprazole.
Obtained by screening with pharmacological model. Through combinatorial chemistry, a large number of chemical libraries with different structures are constructed without separation of mixtures. Through high-throughput screening, the components are found to have pharmaceutical activity and then separated, and the structure of the active compound is determined.
Designed according to physiological and pathological mechanisms. For example: the study of fluorouracil takes the nucleotide uracil synthesized from DNA or RNA as the lead compound, and replaces the hydrogen at position 5 with fluorine, making it a metabolic antagonist of the normal metabolites of the organism, and is used as an antitumor drug