CAS number：78628-80-5
molecular formula：C21H26ClN
molecular weight：327.89
EINECS number：616-640-4

English synonyms:

lamosil;n-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-1-naphthalenemethanamin(e)-1-naphthalenemethanaminmon;Terbinafine Hydrochloride ( China GMP,EDMF Available);Terbinafine-d7 HCl;（E）-N（- 6,6-Dimethyl-2-hepten-4-ynyl）- N-methyl-1-naphthylmethylamine Hydrochloride[Terbinafine Hydrochloride];N-[(2E)-6,6-Dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine hydrochloride;N-[(E)-6,6-Dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine Hydrochloride;TRANS-N-(6,6-DIMETHYL-2-HEPTEN-4-YNYL)-N-METHYL-1-NAPHTHYLMETHYLAMINE HYDROCHLORIDE

Related categories:

Pharmaceutical raw materials; terbinaphol; antibiotics; intermediates; terbinafine; intermediates of original drugs; antifungal drugs; antipyretic and analgesic drugs; raw materials and their intermediates; antiallergic drugs; Small molecule inhibitors; chemical raw materials; antifungal; antiviral and anti-infective; pharmaceutical raw materials; pharmaceutical allylamine antifungal drugs; impurity reference substances; external skin raw materials; organic chemical raw materials; pharmaceutical chemicals; reference substances; medical raw materials; medicinal raw materials;
Acetylenes;Antifungals for Research and Experimental Use;Biochemistry;Functionalized Acetylenes;Terbinafine;
Raw materials; allylamine antifungal drugs; antibacterial drugs; compounds: raw materials: antipyretic and analgesic; raw materials; skin antibacterial raw materials; chemical industry; medical raw materials; synthetic antibacterial drugs; drug impurities and intermediates; main products; chemical intermediates Industrial raw materials; pharmaceutical, pesticide and dye intermediates; pharmaceutical and chemical industries; organic chemistry; chemical intermediates; chemical reagents; organic chemical raw materials; dermatology; conventional raw materials; terbinafine hydrochloride; antiviral intermediates; Target compounds; Reagents; Chemical raw materials-APIs; Pharmaceutical chemicals; Products with pictures; Antifungal; APIs; Amines; Aromatics; Intermediates & Fine Chemicals; Pharmaceuticals; LAMISIL; API; 78628-80-5

Introduction：

Terbinafine hydrochloride is an allylamine broad-spectrum antifungal drug used in dermatology. Currently, it is sold in more than 90 countries around the world. It can specifically interfere with the early biosynthesis of fungal sterols, selectively inhibit the activity of fungal squalene epoxidase, and hinder the epoxidation reaction of squalene in the process of fungal cell membrane formation, thereby achieving killing or Inhibits the action of fungi. It is suitable for the treatment of skin candidiasis, such as tinea manuum, tinea pedis, jock itch, tinea corporis and tinea versicolor, and it is also the best medicine for treating onychomycosis.

●  Terbinafine hydrochloride is an allylamine drug with broad-spectrum antifungal activity. It has significant curative effects on athlete's foot, onychomycosis, tinea corporis, jock itch, tinea versicolor, etc. caused by fungi, and can also be used for bronchial asthma , Asthmatic bronchitis and emphysema.

API Active Pharmaceutical Ingredients
Obtained from natural medicine. Natural medicine is an important part of medicine. For example, artemisinin, an effective antimalarial ingredient isolated from the traditional Chinese medicine Artemisia annua.
Take existing drugs as first-comers.
1) Discover the active ingredients of the drug from the side effects of the drug. For example, the phenothiazine antipsychotic chlorpromazine and its analogs are developed from the sedative side effects of the similarly structured antihistamine promethazine.
2) Obtained through drug metabolism research. For example, the metabolites of antidepressants imipramine and amitriptyline, norimipramine and noramitriptyline, have stronger antidepressant effects than the original drug; oxazepam is the active metabolite of diazepam.
3) Leading with existing breakthrough drugs. For example, the research on lansoprazole and other prazols is based on omeprazole, which is more active than omeprazole.
Obtained by screening with pharmacological model. Through combinatorial chemistry, a large number of chemical libraries with different structures are constructed without separation of mixtures. Through high-throughput screening, the components are found to have pharmaceutical activity and then separated, and the structure of the active compound is determined.
Designed according to physiological and pathological mechanisms. For example: the study of fluorouracil takes the nucleotide uracil synthesized from DNA or RNA as the lead compound, and replaces the hydrogen at position 5 with fluorine, making it a metabolic antagonist of the normal metabolites of the organism, and is used as an antitumor drug