CAS number：50-81-7
molecular formula：C6H8O6
molecular weight：176.12
EINECS number：200-066-2

English synonyms

3-Keto-L-gulofuranolactone;3-Oxo-L-gulofuranolactone;3-oxo-l-gulofuranolactone(enolform);Adenex;Allercorb;Antiscorbic vitamin;antiscorbicvitamin;Antiscorbutic vitamin

Related categories

Amino Acids and Derivatives; CE Reagents; Chromatographic Solvents; Food and Beverage Standards; Reagents and Supplements; Industrial Raw Materials; Standard products; plant extracts; chemicals; food and feed additives; nutrients; plant extracts; vitamin c; biochemical reagents; medical raw materials; breeding and feed processing raw materials; organic chemical raw materials; Classes; nutritional enhancers; feed additives; vitamin additives; antioxidants; vitamins; pharmaceutical raw materials; small molecule inhibitors; small molecule inhibitors, natural products; biochemistry; custom synthetic products; organic chemistry; acids; corrosion and alkalinity Reagents; professional reagents; pharmaceutical excipients; other pharmaceuticals; raw materials; organic synthesis; intermediates; vitamin series; raw material intermediates - APIs; biochemical reagents - vitamins; cell biology - cell oxidative stress; additives 1; medical Raw materials;Others;Reference substance-Chinese medicine reference substance;Standard substance-Chinese medicine standard substance;Pharmaceutical impurities and intermediates;PHARMACEUTICALS;Food and Feed Additive;Acid;Vitamins and Derivatives;Antioxidant;Biochemistry;Sugar Acids;Sugars;Vitamins;Nutritional Supplements ;Vitamin Ingredients;Food Additives, Medicine;Carbohydrates & Derivatives;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Used in medicine and Food Additives;vitamin;Inhibitors;raw materials; Pesticide and dye intermediates; organic intermediates; additives; organic chemical raw materials; chemical raw materials; content products; impurity reference substances; chemical reagents; raw materials and intermediates; chemicals; general biochemical reagents-vitamins; vitamin C series; Medical use; clinical testing standard substance;

Introduction

Vitamin C, also known as L-ascorbic acid, is an essential nutrient for higher primates and a few other organisms. Ascorbic acid is metabolically produced in most living organisms, but humans are the most notable exception. The most widely known is that a lack of vitamin C causes scurvy. The pharmacophore of vitamin C is ascorbate ion. In living organisms, vitamin C is an antioxidant, because it can protect the body from the threat of oxidants, and vitamin C is also a coenzyme.

Chemical properties

White or slightly light yellow crystal or crystalline powder, odorless, with sour taste. Melting point 190～192℃, optical rotation αD20=+21°～+22°. Soluble in water, soluble in ethanol, insoluble in chloroform, ether and benzene. The pH value of 5% aqueous solution is 2.2-2.5. It is relatively stable in dry air, and its aqueous solution is unstable, especially in neutral or alkaline solutions, it is quickly oxidized, and it will accelerate oxidation when exposed to light, heat, and metal ions such as copper and iron. Rat oral LD505g/kg, ADI value without special regulations (FAO/WHO, 1994). 

Chemical properties

White or slightly light yellow crystal or crystalline powder, odorless, with sour taste. Melting point 190～192℃, optical rotation αD20=+21°～+22°. Soluble in water, soluble in ethanol, insoluble in chloroform, ether and benzene. The pH value of 5% aqueous solution is 2.2-2.5. It is relatively stable in dry air, and its aqueous solution is unstable, especially in neutral or alkaline solutions, it is quickly oxidized, and it will accelerate oxidation when exposed to light, heat, and metal ions such as copper and iron. Rat oral LD505g/kg, ADI value without special regulations (FAO/WHO, 1994). 

Use

●  As an antioxidant, it can be used in fermented flour products with a maximum dosage of 0.2g/kg; it can also be used in beer with a maximum dosage of 0.04g/h. It can also be used as food nutrition enhancer.

●  water soluble antioxidant

●  Used as chemical reagent and chromatographic analysis reagent

●  Vitamin medicine, used to prevent and treat scurvy, and also used as an auxiliary effect for various acute and chronic infectious diseases and purpura

●  Vitamin C participates in the complex metabolic process of the body, can promote growth and enhance resistance to disease. my country's regulations can be used to strengthen sandwich hard candy, the dosage is 2000 ~ 6000mg/kg; in high iron cereals and their production. 800-1000mg/kg in food products (limited to 50g of this kind of food per day); 300-500mg/kg in fortified infant food; 200-400mg/kg in fortified canned fruit; The dosage in fortified drinking liquid and milk beverage is 120-240mg/kg; the dosage in fortified fruit puree is 50-100mg/kg. In addition, this product has a strong reducing property and can be used as an antioxidant.

●  Vitamin C participates in the complex metabolic process of the body, can promote growth and enhance resistance to disease, can increase poultry egg production and improve eggshell quality. When animals lack vitamin C, symptoms such as loss of appetite, growth stagnation, dull fur, and anemia will occur. In addition, this product has a strong reducing property and is a good antioxidant.

●  Synthetic medicinal vitamin C is exactly the same as natural vitamin C. This product can promote the transformation of folic acid into tetrahydrofolate, which is beneficial to the synthesis of nucleic acid and the production of red blood cells. It can also reduce ferric ions to ferrous ions, which is easy to be absorbed by the human body and is also beneficial to the generation of cells. Vitamin C is involved in the production of collagen in the body. It can neutralize toxins, promote the production of antibodies, and enhance the detoxification function of the body. In medicine, it is mainly used for the prevention or treatment of scurvy, and for caries, gingival abscess, anemia, growth retardation and other diseases caused by insufficient anti-blood acid.

purposes: vitamin drugs. Participate in the oxidation-reduction process in the body, reduce the fragility of capillaries, and increase the body's resistance. For vitamin C deficiency, fever, chronic wasting disease, etc.

Standard reagents for the determination of arsenic, iron, phosphorus and iodine, chromatographic analysis reagents, antioxidants, masking agents, reducing agents

Production method

●  Vitamin C for medicinal purposes is synthetic. There are many methods of synthesis. Generally, D-sorbitol is made from glucose, and then oxidized and fermented by Acetobacter Suboxydans to generate L-sorbose, which is condensed to generate diacetone-L-sorbose, and then oxidized to generate diacetone-2-ketone- L-gluconic acid is then esterified into 2-keto-L-gluconate methyl ester, reacted with sodium methoxide to generate sodium ascorbate, and heated with hydrochloric acid to produce ascorbic acid. This product will be excreted from the urine if it is administered to animals in an amount exceeding the physiological needs. Tolerated even in large doses given orally, subcutaneously or intravenously. Oral administration of 0.5-1.0g/kg to mice per day for 7 consecutive days, or a large amount of administration to livestock, no poisoning was found.

●  Vitamin C widely exists in fresh vegetables and fruits, and industrial production usually uses chemical and enzymatic methods. Glucose is hydrogenated and reduced to D-sorbitol under the catalysis of nickel, and then oxidized and fermented by acetic acid bacteria at 30-34°C and pH5.2-5.5 to generate L-sorbose, which is present in the presence of oleum and At -8°C, L-- dissolves in acetone and condenses with it to form diacetone sorbose, and then oxidizes with sodium hypochlorite to form diacetone-2-keto-L-gulose under the catalysis of nickel sulfate at 75-80°C Acid, and finally hydrolyzed under acidic conditions to generate 2-keto-L-gulonic acid, and then to obtain ascorbic acid.

●  Vitamin C widely exists in fresh vegetables and fruits, and industrial production methods usually use chemical and enzymatic methods. Glucose is hydrogenated and reduced to D-sorbitol under the catalysis of nickel, and then oxidized and fermented by acetic acid mold at 30~34°C and Ph value 5.2~5.5 to generate L-sorbose; in the presence of oleum and - At 8°C, L-sorbose is dissolved in acetone and condensed with it to form diacetone sorbose; under the catalysis of nickel sulfate and at 75-80°C, it is oxidized with sodium hypochlorite to form diacetone-2-keto-L-gulose Acid; Finally, it is hydrolyzed under acidic conditions to generate 2-keto-L-gulonic acid, and then ascorbic acid is obtained.

●  Glucose is hydrogenated and reduced to D-sorbitol under the catalysis of nickel, and then oxidized and fermented with acetic acid mold at 30-34°C and the pH value is 5.2-5.5 to generate L-sorbose. In the presence of oleum and at -8°C, L-sorbose and acetone are condensed into diacetone sorbose; under the catalysis of nickel sulfate and at 75-80°C, oxidized with sodium hypochlorite to form diacetone-2-keto-L , Gulonic acid; finally hydrolyzed under acidic conditions to generate 2-keto-L-gulonic acid; and then get ascorbic acid.