CAS number：103745-39-7
molecular formula：C14H17N3O2S
molecular weight：291.37
EINECS number：816-154-4

English synonyms

Fasudil Hydrochloride Injection;5-(AZEPAN-4-YLSULFONYL)ISOQUINOLINE DIHYDROCHLORIDE;Fasudil HCI;5-(1,4-diazepan-4-ium-1-ylsulfonyl)isoquinoline;Fasudil Hydrchloride;1-(5-ISOQUINOLINE-SULFONYL)-HOMOPIPERAZINE;at877;hexahydro-1-(5-isoquinolinylsulfonyl)-1h-4-diazepine

Related categories

Anti-anginal drugs; cardiovascular and cerebrovascular drugs; drugs; raw materials; small molecule inhibitors; quaternary ammonium salts, phase transfer catalysts Phase Transfer Catalysts; ;Signalling;Angiogenesis and Metastasis;Intracellular signaling;APIs;ERIL;Pharmaceutical APIs;APIs

Introduction

A drug called fasudil effectively blocks the feedback loop, protecting synapses and memory in animal models of Alzheimer's, while reducing the amount of beta-amyloid in the brain, researchers say. I hope that the research will enter the clinical stage as soon as possible, and that Alzheimer's disease will be completely extinct in our generation.

Chemical properties

Fasudil Hydrochloride: C14H17N3O2S?HCl. [105628-07-7]. It crystallizes from water with a melting point of 220.5°C. White crystalline powder, melting point 219.3°C. The solubility in water can reach 2×10-2mol/L when Ph=5.0～7.0. Acute toxicity LD50 mice, rats (mg/kg): 67.5, 59.9 intravenous injection; 124.5, 123.2 subcutaneous injection; 273.9, 335.0 oral administration.

Use

●  Calcium antagonists. For vasospasm after subarachnoid hemorrhage surgery, it can also be used for neuroprotection, acute cerebral arterial embolism, chronic cerebral infarction and angina pectoris.

Production method

●  Isoquinoline is sulfonated by oleum, and the generated sulfonic acid is converted into sulfonyl chloride, and then reacted with diazepam to obtain the product.