CAS number：132112-35-7
molecular formula：C17H26N2O.ClH.H2O
molecular weight：328.88
EINECS number：663-286-1

English synonyms

(S)-1-propyl-2',6'-dimethylanilinoformoxylpiperidine monohydrochloride monohydrate;(S)-1-propyl-2',6'-dimethylanilinoformoxylpiperidine,monohydrochloride,monohydrate;(S)-Ropivaxaine hydrochloride;(S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride;Ropivacaine hydrochloride;(2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide Hydrochloride Hydrate;LEA-103;(S)-ropivacaine hydrochloride hydrate

Related categories

Organic chemical intermediates; pharmaceutical raw materials - scientific research raw materials; anesthetic Narcotic; raw materials; local anesthesia series; intermediates; other scientific research raw materials; pharmaceutical raw materials;
Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Anesthetics;Inhibitors;
Small molecule inhibitors, natural products; amide local anesthetics; synthesis; API; pharmaceutical raw materials and intermediates; intermediates; raw materials; daily chemicals; medical raw materials; chemical reagents

Introduction

Ropivacaine hydrochloride is a long-acting local anesthetic of the amide class. Its fat solubility is greater than that of lidocaine and less than that of bupivacaine, and its anesthetic strength is 8 times that of procaine. Because the products metabolized in the liver also have a local anesthetic effect, the effect is longer. It is mainly used for regional block anesthesia and epidural anesthesia, and for postoperative and labor analgesia.

Chemical properties

Use

●  Ropivacaine hydrochloride is suitable for:
Anesthesia for surgery
-----Epidural anesthesia, including cesarean section
-----Subarachnoid anesthesia
acute pain control
-----Continuous epidural infusion or intermittent single dose, such as postoperative or vaginal labor analgesia
-----Regional block

Production method

API Active Pharmaceutical Ingredients
Obtained from natural medicine. Natural medicine is an important part of medicine. For example, artemisinin, an effective antimalarial ingredient isolated from the traditional Chinese medicine Artemisia annua.
Take existing drugs as first-comers.
1) Discover the active ingredients of the drug from the side effects of the drug. For example, the phenothiazine antipsychotic chlorpromazine and its analogs are developed from the sedative side effects of the similarly structured antihistamine promethazine.
2) Obtained through drug metabolism research. For example, the metabolites of antidepressants imipramine and amitriptyline, norimipramine and noramitriptyline, have stronger antidepressant effects than the original drug; oxazepam is the active metabolite of diazepam.
3) Leading with existing breakthrough drugs. For example, the research on lansoprazole and other prazols is based on omeprazole, which is more active than omeprazole.
Obtained by screening with pharmacological model. Through combinatorial chemistry, a large number of chemical libraries with different structures are constructed without separation of mixtures. Through high-throughput screening, the components are found to have pharmaceutical activity and then separated, and the structure of the active compound is determined.
Designed according to physiological and pathological mechanisms. For example: the study of fluorouracil takes the nucleotide uracil synthesized from DNA or RNA as the lead compound, and replaces the hydrogen at position 5 with fluorine, making it a metabolic antagonist of the normal metabolites of the organism, and is used as an antitumor drug