Benzimidazole cas 51-17-2

Product name: Benzimidazole

CAS: 51-17-2

Molecular formula: C7H6N2

EINECS number: 200-081-4

Benzimidazole Chemical Properties

Applications

Benzimidazole compounds are widely used in the fields of pesticides, medicines, and materials. Moreover, their special imidazole structure plays an important role in the research of various drugs, especially in the development of PARP inhibitors.

Chemical properties

Benzimidazole is a flaky crystal with an m.p. of 170°C and is soluble in water and ethanol.

Uses

1. Benzimidazole can be used to prepare the intermediate imidazole of fungicides such as imazalil and prochloraz.

2. Organic synthesis intermediate. Reagent for determining cobalt

3. Used to synthesize drugs such as vitamin B12 and prepare polymer compounds, etc.

4. Pesticide intermediate: fungicide intermediate: triazole fungicide

Production method

1. Obtained by cyclization of o-phenylenediamine and formic acid. Heat the mixture of o-phenylenediamine and formic acid in a water bath for 2h, cool, adjust the pH to 10 with 10% sodium hydroxide solution, filter out the precipitated solid, and wash with cold water to obtain a crude product. Boil the crude product with water, add activated carbon for decolorization, filter while hot, cool the filtrate to room temperature, filter, wash with cold water, and dry at 100℃ to obtain the finished product. The crude product yield is 90%.

2. The preparation method is to add crushed o-phenylenediamine into the reactor, then pump in formic acid, maintain the reaction temperature at 95-98℃ and stir for 2h, cool to precipitate crystals, and then neutralize with 10% NaOH to slightly alkaline, cool and filter, wash with water, and dry to obtain benzimidazole.