Introduction

Glycerophosphocholine (GPC) is a water-soluble small molecule substance that exists normally in the human body. It is an important neurotransmitter. Choline is a water-soluble vitamin B family, which plays an important role in the brain and nervous system. Studies have shown that GPC plays an important role in the production of certain hormones and neurotransmitters such as acetylcholine and human growth hormone, thereby supporting the function of the brain and nervous system.

Glycerylphosphorylcholine Chemical Properties

Physical and chemical properties

Glycerylphosphorylcholine (GPC) is miscible with water, soluble in methanol and ethanol, insoluble in chloroform, ether, oil, etc., and has no characteristic absorption under ultraviolet visible light. GPC content determination methods include high performance liquid chromatography (equipped with evaporative light scattering detector or differential refractive index detector) and digestion phosphorus determination method.

Pharmacological effects

Choline glycerol is a naturally occurring intermediate in phospholipid metabolism in the human body. It exists in cells and is distributed throughout the human body. It is composed of choline, glycerol, and phosphoric acid. It is a major form of choline storage and is recognized as a source of choline. Because it is an endogenous substance, its toxic side effects are extremely low. After absorption, choline glycerol is decomposed into choline and glycerol phosphate by the action of enzymes in the body: choline participates in the biosynthesis of acetylcholine, which is a type of neurotransmitter; glycerol phosphate is the precursor of lecithin and participates in the synthesis of lecithin. The main pharmacological effects include protecting the metabolism of choline, ensuring the synthesis of acetylcholine and lecithin in the nerve membrane, improving blood circulation, and improving cognitive and behavioral responses for patients with brain capillary nerve damage. In this field, no better new drugs have been launched or developed.

Biological Functions

Glycerolphosphocholine is not only one of the main permeabilizers of renal medullary cells, but also can change the concentration of permeabilizers inside and outside cells in parallel. This is beneficial to the health of cerebrovascular vessels, especially to behavioral and emotional disorders caused by brain degeneration. Glycerolphosphocholine has the potential to treat and prevent a variety of biochemical lesions. Researchers have found that it can change the structure of phosphate lipid compounds in neuronal membranes, and found that it has a unique effect of relieving physical tension in the factors related to neurological tissue degeneration syndrome.

Applications

Glycerol phosphocholine not only provides high levels of choline required by brain cells and nerve cells, but also protects their cell walls. Alzheimer's patients mainly show decreased memory and cognitive function, accompanied by a variety of complications, such as mobility impairment, nervous system disorders and other functional disorders. Clinical pharmacological test results and clinical trials have confirmed that glycerol phosphocholine is of great help to the brain's cognitive ability and memory function.

Uses

Digestive system drugs/adjuvant drugs for liver diseases

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