CAS number：78-70-6
molecular formula：C10H18O
molecular weight：154.25
EINECS number：201-134-4

English synonyms

6-Octadien-3-ol,3,7-dimethyl-1;beta-Linalool;b-Linalool;femanumber2635;Linalol;linalool B;Linalool ex ho oil;Linalool ex orange oil

Related categories

Plant biochemical extracts; pharmaceutical raw materials; flavors and fragrances; flavors; alcohols, aldehydes, ketones; essential oils; plant extracts; traditional Chinese medicine reference substances; synthetic flavors; daily necessities; flavors and flavors; food additives; other oxygenated compounds; standard products; Cosmetic fragrances;Nutrition studies;Plant extracts;Reference substances;Flavors and fragrances;Chemical reagents;Analytical reagent standards;Organic chemical raw materials;Biochemical reagents-other chemical reagents;Daily chemical raw materials;AcyclicMonoterpenes;Biochemistry;Terpenes;alcoholFlavor;Alcoholic flavors; Edible flavors (flavor enhancers); Natural equivalent flavors and artificial flavors; Theobromacacao (Chocolate); Vaccinium myrtillus (Bi; Acyclic; Alkenes; Alliumsativum (Garlic); Artemisiavulgaris; Citrusaurantium(Sevilleorange);Medical raw materials; standard products-standard products of traditional Chinese medicine; pesticides; standard products-standard products of traditional Chinese medicine; cosmetic additives, fragrances, essences; pharmaceuticals, pesticides and dye intermediates; materials; chemical raw materials; monomer fragrances; chemical materials Chemicalbook; alcohols, aldehydes , ketones; organic chemical raw materials; aldehydes, alcohols, ketones; natural;
Curcumalonga (Turmeric); Elettaria Cardamomum (Cardamom); Ephedrasinica; Humuluslupulus (Hops); Lavandulaangustifolia (Lavendartea); Melaleucaalternifolia；(Elderberry);Usedinessentialoilandsoapfragrance;chemicalreagent;pharmaceuticalintermediate;phytochemical;referencestandardsfromChinesemedicinalherbs(TCM).;standardizedherbalextract;Cosmetics;

Introduction

Linalool, also known as linalool and linalool, is a terpene alcohol and one of the well-known fragrance compounds. It is a mixture of two isomers (α-linalool and β-linalool). It is extracted from camphor oil or synthesized from α-pinene or β-pinene in turpentine. Colorless oily liquid with sweet and fresh floral fragrance, like lily-of-the-valley fragrance. Soluble in organic solvents such as ethanol, ethylene glycol and ether, but insoluble in water and glycerol. Isomerization is prone to occur, but it is relatively stable in bases. Density (25°C) 0.860～0.867, refractive index (20°C) 1.4610～1.4640, optical rotation (20°C) -12°～-18°, boiling point 197～199°C, flash point (open type) 78°C. Linalool with an alcohol content of more than 95% is an important spice and is used in the fragrance industries such as floral fragrances, perfumes, and soaps. It is widely used in blending lily, clove, sweet pea, orange blossom, etc. Fragrance, oriental fragrance, aldehyde fragrance blending fragrance, cosmetic fragrance, as food fragrance, can also be used as lemon, lime, orange, grape, apricot, pineapple, plum, peach, cardamom, cocoa, chocolate fragrance. The alcohol content of 92.5% is the raw material for isophytol, an important intermediate in the preparation of vitamin E in the pharmaceutical industry. It can also be used as a raw material for the manufacture of very valuable perfumes such as linalyl acetate. Linalool is an open-chain tertiary terpene alcohol with two double bonds. Due to the presence of asymmetric carbon atoms, it has three optical isomers. In nature, all three isomers exist, of which the l-isomer is the most abundant, accounting for about 70% to 80% of the three. L-body is mostly found in linalool oil (about 80-90%), yellow orchid, lavender oil, white lemon oil, neroli oil, saffron oil, galore oil, lemon oil, rose oil, ylang-ylang In essential oils such as ylang-ylang oil; d-body mostly exists in coriander oil (about 60% to 70%), sweet orange oil, nutmeg oil, palmarosa oil and other essential oils; dl-body exists in saffron, jasmine in essential oils. All three are colorless oily transparent liquids. There are lily and citrus-like aroma. In addition, because its hydroxyl group is close to the allyl group, it has a great influence on its chemical properties. In the presence of metal sodium, in ethanol solution, it is easily reduced to form dihydromyrcene; in the presence of platinum catalyst or Ruanlai nickel catalyst, it can be reduced to tetrahydrolinalool to become saturated alcohol. Because it is a tertiary alcohol, it can undergo isomerization in a strongly acidic medium; while in a weakly acidic medium, it can be dehydrated to form an ester. Stable in alkaline medium. Oral LD502790mg/kg for rats.

Chemical properties

Colorless liquid with a bergamot (bergamot) fragrance. Insoluble in water, miscible with ethanol and ether.

Use

●  For the preparation of fragrances such as cosmetics, soaps, detergents, food, etc.

●  GB276011996 stipulates that it is temporarily allowed to use edible spices. Mainly used for the preparation of pineapple, peach, chocolate and other flavors and spice flavors.

●  Often used as a starting material in the total synthesis of agelasineE analogs and vitamin E derivatives.

●  It is widely found in the flowers, fruits, stems, leaves, roots and green calyx of plants. It is widely used, not only for all floral flavors, such as sweet bean flower, jasmine, lily of the valley, lilac, etc., but also for It can also be used in the preparation of orange leaf, bergamot, lavender in non-flower flavors such as fruit Chemicalbook-flavored, light-flavored, woody-flavored, aldehyde-flavored, oriental, amber-flavored, orchid-flavored, fragrant-flavored, etc. , mixed lavender oil and other artificial essential oils. Mostly used in soap essence. Can also be used for food flavors.

●  Linalool is an important spice, a raw material for blending various artificial essential oils, and is also widely used in the manufacture of various esters of linalool. It plays an important role in cosmetic formulations such as linalool and base ester perfumes. Linalool is oxidized to form citral, which can also be used to synthesize many other fragrances.

Production method

●  Commercially available linalool is mainly isolated from natural essential oils such as galaxian oil, rosewood oil, coriander oil, and linalool oil. The crude linalool can be obtained by fractional distillation with a high-efficiency fractionation column, and the second fractionation is performed to obtain a finished product with a content of more than 90%. The synthesized linalool uses β-pinene as the raw material, which is pyrolyzed to generate myrcene, which is treated with hydrogen chloride to generate a mixture including linalyl chloride. Linalool is obtained by the action of linalyl chloride and caustic potash (or potassium carbonate, calcium carbonate).

●  It can be freed from linalool oil: use acetyl boric anhydride to make linalool in linalool oil into acid borate, and then obtain the finished product after distillation, recrystallization and saponification. Dehydrolinalool is obtained by condensing 6-methyl-5-hepten-2-one with sodium acetylene, and then reducing it with metallic sodium in wet ether solution to obtain linalool.

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